Diabetes Protection Human Hormone Blocker Found To Help Prevent Obesity And Diabetes
| Human Hormone Blocker Found To Help Prevent Obesity And Diabetes |
|
A new study finds that a chemical found in the body is capable of promoting weight loss, improving insulin resistance and reversing diabetes in an animal model. The hormone is gastric inhibitory polypeptide (GIP) receptor blockade.
GIP is a peptide hormone that is secreted in response to food. It inhibits the secretion of acids stimulates the releases insulin as part of the digestive process in response to food. It is found in a variety of tissues, including the intestine, heart, stomach, brain and in adipose (fat). While the significance of its action is largely unknown, its potent and prolonged stimulation after a high-fat diet has led researchers to speculate it may play a key role in metabolizing fat. Research has shown that high fat feeding results in elevated circulating GIP concentrations, traits often found in patients who are obese with diabetes. GIP also effects the growth of fat cells. Other studies have shown that mice injected with the GIP receptor antagonist - (Pro3)GIP - can reverse or prevent many of the metabolic abnormalities associated with obesity. A new study examined whether prolonged GIP receptor antagonism using daily injections of (Pro3) GIP was able to reverse well established diet-induced obesity and related metabolic abnormalities. Methodology The researchers used a model for diet-induced obesity that has been used extensively alongside genetic models and has close parallels with obesity, increasingly found in humans who consume a high-fat, energy-rich diet. In this model, young (8-week old) male, age matched mice were age-divided into groups and housed individually in an air-conditioned room at 22¡Ó2¢XC with a 12 hour light: 12 hour dark cycle. Experimental animals had free access to drinking water and a high fat diet (45 percent fat, 20 percent protein and 35 percent carbohydrate; percent of total energy of 26.15kj/g). Age-matched control mice from the same colony had free access to a standard rodent maintenance diet (10 percent fat; 30 percent protein; 60 percent carbohydrate; percent of total energy of 12.99kj/g.). The two were used for comparison purposes. Prior to the study, mice were maintained on a high fat diet for 160 days. In addition, a separate set of mice were maintained on a high fat diet for 112 days prior to measuring circulating GIP and GLP-1 levels. On both occasions, obesity and diabetes were clearly evident. The mice which had previously been fed a high fat diet for 160 days received only daily injections of either saline or (Pro3)GIP over a 50-day period. Food intake and body weight were recorded daily while plasma glucose and insulin concentrations were monitored at 5-7 day intervals. Blood was taken on day 50 to measure cholesterol, triglycerides, glucagon (the hormone involved in metabolizing carbohydrate), corticosterone (involved with carbohydrates in the liver) and circulating adipokines (which play a key role in obesity-related diseases). Glucose tolerance and insulin sensitivity tests were performed at the end of the study period. The metabolic response of both groups of mice was also analyzed. Key Findings Highlights of the research findings include the following: Compared with the standard rodent diet (control), the mice that were fed the high-fat diet for the previous 160 days exhibited increased body weight, energy intake, and circulating glucose concentrations. The levels remained elevated throughout the study. The cholesterol and triglycerides levels increased at day 50. This study showed that blocking GIP activity using (Pro3)GIP in mice with established, high fat diet-induced obesity and diabetes results in significant weight loss, improvement of insulin resistance and amelioration of diabetes. These findings represent an interesting new approach to the treatment of obesity and metabolic disturbances. According to the research team¡¦s Nigel Irwin, Ph.D., "Interestingly, possible parallels exist with the benefits of Roux-en-Y surgery (gastric bypass surgery) in treating gross obesity and associated diabetes in people. In this procedure, nutrients surgically bypass the area of the small intestine, resulting in a deficiency of circulating GIP. We are looking to better understand how and why." The new study is entitled, "GIP Receptor Antagonism Reverses Obesity, Insulin Resistance, and Associated Metabolic Disturbances Induced in Mice by Prolonged Consumption of High-Fat Diet." It was conducted by Paula L. McClean, Nigel Irwin, Roslyn S. Cassidy, Victor A. Gault and Peter R. Flatt, all of the School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland, UK; and Jens J. Holst, Department of Medical Physiology, The Panum Institute, University of Copenhagen, Copenhagen, Denmark. It is entitled The findings appear in the American Journal of Physiology - Endocrinology and Metabolism (doi:10.1152/ajpendo.00460.2007), a publication of the American Physiological Society (The article from:sciencedaily.com) Comments (21)
  written by juicycoutures, April 26, 2011
Are you still complaining about the out-of-date style and plain-looking color? Don’t worry. juicy couture sale is the God-bestowed angel to fresh your life with fashionable designs and colorful patterns. You can find as many beautiful juicy couture handbags as you can imagine.Enjoy yourself but don’t forget the way back home!
written by ralphlauren, April 26, 2011
polo Ralph Lauren, as the world famous casual-fashion clothes series, is people’s best loved casual wearing brand. With the handsome bright style for men and stylish sweet style for ladies, Ralph Lauren outlet is always customers’ first choice of purchasing. Also it’s a great honor to tell that Ralph Lauren online shop now is right on hot promotion sale, you can enjoy a surprisingly great discount and our considerate fast delivery and free shipping.
 written by coach purses, May 09, 2011
Coach outlet infuse the inimitable modern fashion charm into the royal quality of a huge series of Coach handbags and Coach purses which build an good reputation for Coach outlet Canada. It makes all ladies to keep stylish and gorgeous in their everyday look possible. You can find plenty of your facorites Coach online easily and all on discount prices with free shipping here.
 written by mbt shoes sale, May 15, 2011
I also so familiar with the academic LiShaoJun about grass-roots topic dating back to world of push grass. mbt trainers uk Perhaps this qingqing herbs that constitutes the grass-roots deep ecology basis.MBT Goti Boot I also seems to be caught LiShaoJun from poetic dynamics.
written by mbt shoes sale, May 29, 2011
really difficult of the Passover. MBT Shoes Discount For example, a worker family background lad, if they do not have how old ambition, Cheap Oakley Sunglasses then you should find a girl with oneself condition similar get married to calculate, try not to dream find a multimillionaire 'family when the scarabaeoidea.
 written by LouisVuitton, June 01, 2011  written by tory burch uk, August 04, 2011
Department of Medical Physiology, The Panum Institute, University of Copenhagen, Copenhagen, Denmark. tory burch flats outlet It is entitled The findings appear in the American Journal of Physiology - Endocrinology and Metabolism (doi:10.1152/ajpendo.00460.2007), a publication of the American Physiological Society
 written by Coach Outlet, August 09, 2011
Our Coach Outlet Online store can steadily supply Coach handbags with high quality, various styles as well as dicount prices.Now kinds of Coach Bags Outlet are on sale.The Coach Outlet with Low Price and you will get the best service!
 written by Juicy Couture Handbags, August 09, 2011
You can find a number of different styles in our online Juicy Couture Outlet store and if you're looking for Cheap Juicy Couture then you'll probably be able to find something which suits you and your style. Cheap Juicy Couture welcome you!
 written by coachoutlet, September 16, 2011
coach julia op art glam tote bag chocolate
coach julia perry black coach julia perry black my-juicycoutureoutlet  written by nike air shox, October 03, 2011
probably be able to find something w adidas football shoes
written by Nike football sneaker, October 03, 2011
[url= Nike]http://gestion.cc/Nike_Mercurial_Vapor_1.htm]Nike football sneaker
written by Nike football sneaker, October 03, 2011
n find a number of different stNike football sneaker
 written by Black bailey button ugg boots, October 13, 2011 The womens Black bailey button ugg boots is a stylish and glittery take on one of our most famous boots. Covered in sparkly sequins and bound with satin, it is sure to turn heads and stand out in a crowd. All boots in our Ugg bailey button triplet feature a soft foam insole covered with genuine sheepskin. The] has a light and flexible, molded EVA outsole that is infused with metallic flecks and designed for amazing comfort with every step.  written by replica handbags, November 03, 2011
Another great place to look in for cheap snapbacks is thrift stores wool cap. Thrift stores are where you can find used products. When snapbacks hats went out of fashion, many people gave theirs away to such store owners. Therefore, you might be surprised at the extent of variety and designs of you might see in such thrift stores cheap wool cap. It is always worth it checking out these stores too before you resort to an expensive purchase.
 written by office 2010, December 05, 2011  written by 003, December 05, 2011
UK-Dissertation-Help.com offers a better service in writing professional the canada goose sis to a karen millen ll the students. We have great writers as well as researchers who has good subject knowledge and with hands on experience in the respective field which is needed to give the quality product which students expect. Our company is one among the best writing service providers which students can trust on. We never offer students with any plagiarized document or with any below standard work. We ensure that all our work will be professional and as well is original.
 written by wholesale hats, January 03, 2012
Perk up established common will become cooled using a a terrific way to through manufacturers like Outside Look. Without a as few as money 20 well you can acquire an important propensity Lawn Learn head wear. You'll find nothing as you all on your own common lower price fledgling age knitted scarves Top and also a coating due to the fact change for the working weather conditions. If you decide on, think of making use of the idea head wear Exterior To endure Bombshell Container all on your own however the Top blood vessels holding denim jeans , nor silk scarf. More than a wind resistant, more sleek sort of the typical box cover, the idea jacket will take slightly femininity, elegant and elegant hear sadly mindful, is to find be careful about your hair styling right away.
 written by supreme hats, January 03, 2012
Thank you for your sharing，When talking about the bowler cheap hats, the brand name hats gloves is always come into mind.
written by cheap new era hats, January 09, 2012
Perk up established common will become cooled using a a terrific way to through manufacturers like Outside Look. Without a as few as money 20 well you can acquire an important propensity Lawn Learn head wear. You'll find nothing as you all on your own common lower price fledgling age cheap winter hats wholesale Top and also a coating due to the fact change for the working weather conditions. If you decide on, think of making use of the idea head wear Exterior To endure Bombshell Container all on your own however the Top blood vessels holding denim jeans , nor tisa hatsMore than a wind resistant, more sleek sort of the typical box cover, the idea jacket will take slightly femininity, elegant and elegant hear sadly mindful, is to find be careful about your hair styling right away.
Write comment
|
| < Prev | Next > |
|---|
Subscribe to this comment's feed
